The histological and immunohistochemical features of a metastatic mammary carcinosarcoma in a dog - a case report

A carcinosarcoma is a tumor composed of cells morphologically resembling both malignant epithelial and mesenchymal components. An 11-year-old, female, mixed-breed terrier was referred to the clinic with complaints anorexia, vomiting exercise intolerance. Clinically, tumoral masses were seen in mammary glands. During necropsy, multilobulated calcified observed several visceral organs (the liver, kidneys, lungs, small intestines, lymph nodes thyroid) right left (3rd 4th) Immunohistochemically, Thyroglobulin, SMA, TTF-1, S100, CD34, p53 negative areas, however, Ki-67 showed high proliferation, especially areas. While positivity vimentin expression component tumor, cytokeratin (CK7 CK19) expressions tumor. In case carcinosarcoma, there probability that not only carcinomatous part, but also sarcomatous part will metastasize. Despite being uncommon, canine carcinosarcomas should always be considered differential diagnosis mixed tumors, if they include There have been many previous studies dealing metastasis dogs as an aggressive Therefore, we consider this report worthy contribution defined multiple organ carcinosarcoma.